Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukaemia

INTRODUTION: Arsenic trioxide (As2O3) induces a remission in over 90% of patients with relapsed acute promyelocytic leukaemia (APL). To date, only the intravenous (i.v.) preparation of As2O3 has been used. We have recently developed an oral preparation of As2O3 that achieves blood levels of elemental arsenic comparable with those of i.v. As2O3 (Eur J Clin Pharmacol Oct 11, 2002 online). In this study, the efficacy and safety of oral As2O3 were …published_or_final_versio