Using gene-specific probes derived from four mouse γ-crystallin cDNAs, we have examined the regulation of different members of the mouse γ-crystallin gene family during lens development. Our analysis revealed that, while the different γ-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development. This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution γ-crystallins within the lens.link_to_subscribed_fulltex
AbstractThe transcriptional activation of tissue-specific genes during terminal differentiation must...
The promoter of the murine γE-crystallin (γE-Cry) encoding gene (γ(E-cry) was anal...
Gamma-crystallin genes are specifically expressed in the eye lens. Their promoters constitute excell...
Using the polymerase chain reaction (PCR) and RNA blot analysis. we have examined the differential e...
The heterogeneity inherent among γ-crystallins of the mouse lens was investigated by sequence analys...
During hominoid evolution the γ-crystallins of the lens have decreased in quantity as well as comple...
The elements regulating lens-specific expression of the mouse γF-crystallin gene were examined. Here...
Crystallins are the major water-soluble proteins in vertebrate eye lenses. These lens-specific prote...
Previous studies have shown that mouse γF-crystallin sequences -759 to +45, which include the core p...
Gene regulation by enhancers is important for precise temporal and spatial gene expression. Enhancer...
Cell lines derived from the lens generally fail to maintain synthesis of crystallins in long-term cu...
<p>Confocal images show the double-labeled crystallin proteins (red) and DAPI (blue) in the lenses o...
The development of lens structures in transgenic mice (lnl mice) which carry the diphtheria toxin A ...
Crystallins are proteins that accumulate to very high concentrations in the fiber cells of the lens ...
Transgenic mice carrying the diphtheria toxin A gene driven by mouse γ2-crystallin promoter sequence...
AbstractThe transcriptional activation of tissue-specific genes during terminal differentiation must...
The promoter of the murine γE-crystallin (γE-Cry) encoding gene (γ(E-cry) was anal...
Gamma-crystallin genes are specifically expressed in the eye lens. Their promoters constitute excell...
Using the polymerase chain reaction (PCR) and RNA blot analysis. we have examined the differential e...
The heterogeneity inherent among γ-crystallins of the mouse lens was investigated by sequence analys...
During hominoid evolution the γ-crystallins of the lens have decreased in quantity as well as comple...
The elements regulating lens-specific expression of the mouse γF-crystallin gene were examined. Here...
Crystallins are the major water-soluble proteins in vertebrate eye lenses. These lens-specific prote...
Previous studies have shown that mouse γF-crystallin sequences -759 to +45, which include the core p...
Gene regulation by enhancers is important for precise temporal and spatial gene expression. Enhancer...
Cell lines derived from the lens generally fail to maintain synthesis of crystallins in long-term cu...
<p>Confocal images show the double-labeled crystallin proteins (red) and DAPI (blue) in the lenses o...
The development of lens structures in transgenic mice (lnl mice) which carry the diphtheria toxin A ...
Crystallins are proteins that accumulate to very high concentrations in the fiber cells of the lens ...
Transgenic mice carrying the diphtheria toxin A gene driven by mouse γ2-crystallin promoter sequence...
AbstractThe transcriptional activation of tissue-specific genes during terminal differentiation must...
The promoter of the murine γE-crystallin (γE-Cry) encoding gene (γ(E-cry) was anal...
Gamma-crystallin genes are specifically expressed in the eye lens. Their promoters constitute excell...