New Development of Asymmetric Synthesis on the Basis of Activation Method with Chiral Lewis Acid Catalyst : Synthetic Study of Functional Materials Based on Catalytic Asymmetric Conjugate Addition

平成13年度機能研所長リーダーシップ経費(若手奨励研究)による研究の紹介This research project aims to develop a new and effective catalytic asymmetric synthesis on the basis of an activation method using a chiral Lewis acid catalyst. From this viewpoint, an effective asymmetric conjugate addition reaction of electron-rich aromatic compounds to sulfonyl-functionalized enones is examined in the presence of chiral Lewis acids. Furthermore, the synthesis of a variety of optically active derivatives is also performed by the transformation of the β-keto sulfone moiety of conjugated adducts