Drug-DNA complexation as the key factor in photosensitized thymine dimerization

[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals.Spanish Government (CTQ2014-54729-C2-2-P, CTQ2015-70164-P and Severo Ochoa program/SEV-2012-0267) and Generalitat Valenciana (Prometeo II program) are gratefully acknowledged.Cuquerella Alabort, MC.; Lhiaubet, VL.; Miranda Alonso, MÁ.; Bosca Mayans, F. (2017). Drug-DNA complexation as the key factor in photosensitized thymine dimerization. Physical Chemistry Chemical Physics. 19(7):4951-4955. doi:10.1039/c6cp08485kS4951495519