Highly Selective Detection of Nerve-Agent Simulants with BODIPY Dyes

Two chromo-fluorogenic probes, each based on the boron dipyrromethene core, have been developed for the detection of nerve-agent mimics. These chemosensors display both a color change and a significant enhancement of fluorescence in the presence of diethylcyanophosphonate (DCNP) and diisopropylfluorophosphate (DFP). No interference from other organophosphorus compounds or acids has been observed. Two portable chemosensor kits have been developed and tested to demonstrate its practical application in real-time monitoring.We thank the Spanish Government (MAT2012-38429-C04-02) for support. A.B.B. acknowledges the award of a predoctoral FPI fellowship. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. Dr. S. Royo is thanked for support with some of the synthetic chemistry.Barba Bon, A.; Costero Nieto, AM.; Gil Grau, S.; Harriman, A.; Sancenón Galarza, F. (2014). Highly Selective Detection of Nerve-Agent Simulants with BODIPY Dyes. Chemistry - A European Journal. 20(21):6339-6347. doi:10.1002/chem.201304475S63396347202