Cationic Gold Catalyzes Omega-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions

[EN] Orthogonal sigma,pi-bisfunctionalization of terminal alkynes can be achieved with a cationic gold complex in catalytic amounts. First, the terminal C-H bond is transformed to the corresponding bromoalkyne which is then activated toward nucleophilic attack. This reactivity correlates with the structural nature of isolated gold-alkyne complexes.A.L.-P. thanks CSIC for a contract under JAE-doctors program. P.R-M. thanks UPV and ITQ for the concession of a FPI predoctoral fellowship.Leyva Perez, A.; Rubio Marqués, P.; Al-Dejab, SS.; Al-Resayes, SI.; Corma Canós, A. (2011). Cationic Gold Catalyzes Omega-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions. ACS Catalysis. 1(6):601-606. doi:10.1021/cs200168pS6016061