Synaptic and Circuit Mechanisms Governing Corollary Discharge in the Mouse Auditory Cortex

<p>Auditory sensations can arise from objects in our environment or from our own actions, such as when we speak or make music. We must able to distinguish such sources of sounds, as well as form new associations between our actions and the sounds they produce. The brain is thought to accomplish this by conveying copies of the motor command, termed corollary discharge signals, to auditory processing brain regions, where they can suppress the auditory consequences of our own actions. Despite the importance of such transformations in health and disease, little is known about the mechanisms underlying corollary discharge in the mammalian auditory system. Using a range of techniques to identify, monitor, and manipulate neuronal circuits, I characterized a synaptic and circuit basis for corollary discharge in the mouse auditory cortex. The major contribution of my studies was to identify and characterize a long-range projection from motor cortex that is responsible for suppressing auditory cortical output during movements by activating local inhibitory interneurons. I used similar techniques to understand how this circuit is embedded within a broader neuromodulatory brain network important for learning and plasticity. These findings characterize the synaptic and circuit mechanisms underlying corollary discharge in mammalian auditory cortex, as well as uncover a broad network interaction potentially used to pattern neural associations between our actions and the sounds they produce.</p>Dissertatio