<p>The E-protein transcription factors E2A and HEB regulate various cell processes during the development of B and T lymphocytes, including cell differentiation, lineage commitment, recombination of immune receptor genes, proliferation, and survival. B cell development is dependent on E2A from the earliest stages whereas T cell development relies on the cooperative efforts of both E2A and HEB. Established work demonstrates that the timing and dosage of E-protein expression is critical for mediating these diverse functions. The goal of this dissertation is to develop and utilize new genetic tools to manipulate the timing and dosage of E2A and HEB expression in order to enhance our understanding of E-protein function. Here we develop two ...
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. ...
Each TCR Vβ gene is regulated by an individual Vβ promoter, which becomes active prior to V(D) J rec...
AbstractThe E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking...
Thymocyte development is a complex process that requires precise regulation of differentiation and p...
Mature B lymphocytes are capable of acquiring adaptive immune function based upon several selective ...
Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bon...
Early T-cell development is regulated by a complex interplay between transcription factors and devel...
The double-positive (DP) to single-positive (SP) transition during T cell development is initiated b...
SummaryThe double-positive (DP) to single-positive (SP) transition during T cell development is init...
SummaryThe T cell receptor (TCR) is required for positive selection and the subsequent transition fr...
The E2A proteins, E12 and E47, are required for progression through multiple developmental pathways,...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
E-proteins define a distinct class of basic helix-loop-helix transcription factors that are central ...
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. ...
Each TCR Vβ gene is regulated by an individual Vβ promoter, which becomes active prior to V(D) J rec...
AbstractThe E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking...
Thymocyte development is a complex process that requires precise regulation of differentiation and p...
Mature B lymphocytes are capable of acquiring adaptive immune function based upon several selective ...
Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bon...
Early T-cell development is regulated by a complex interplay between transcription factors and devel...
The double-positive (DP) to single-positive (SP) transition during T cell development is initiated b...
SummaryThe double-positive (DP) to single-positive (SP) transition during T cell development is init...
SummaryThe T cell receptor (TCR) is required for positive selection and the subsequent transition fr...
The E2A proteins, E12 and E47, are required for progression through multiple developmental pathways,...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein ...
E-proteins define a distinct class of basic helix-loop-helix transcription factors that are central ...
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. ...
Each TCR Vβ gene is regulated by an individual Vβ promoter, which becomes active prior to V(D) J rec...
AbstractThe E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking...