Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha
- Costa-Silva, Thais Alves da
- Grecco, Simone S.
- Sousa, Fernanda S. de
- Lago, Joao Henrique G.
- Martins, Euder G. A.
- Terrazas, Cesar A.
- Varikuti, Sanjay
- Owens, Katherine L.
- Beverley, Stephen M.
- Satoskar, Abhay R.
- Tempone, Andre G.
DOIAbstract
Three phenylpropanoid dimers (1-3) including two new metabolites were isolated from the extract of the twigs of Nectandra leucantha using antileishmanial bioassay-guided fractionation. the in vitro antiparasitic activity of the isolated compounds against Leishmania donovani parasites and mammalian cytotoxicity and immunomodulatory effects were evaluated. Compounds 1-3 were effective against the intracellular amastigotes within macrophages, with IC50 values of 26.7, 17.8, and 101.9 mu M, respectively. the mammalian cytotoxicity, given by the 50% cytotoxic concentration (CC50), was evaluated against peritoneal macrophages. Compounds 1 and 3 were not toxic up to 290 mu M, whereas compound 2 demonstrated a CC50 value of 111.2 mu M. Compounds 1-...
Add to ORKG