Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats
- Marciano, Renata
- Santamarina, Aline Boveto
- Santana, Aline Alves de
- Correia Silva, Maisa de Lima
- Silverio Amancio, Olga Maria
- Penha Oller do Nascimento, Claudia Maria da
- Oyama, Lila Missae
- Morais, Mauro Batista de
DOIAbstract
Prebiotics may increase intestinal Fe absorption in anaemic growing rats. the present study evaluated the effects of high-performance (HP) inulin and oligofructose on factors that regulate Fe absorption in anaemic rats during the growth phase. Male Wistar rats aged 21 d of age were fed AIN-93G ration without Fe for 2 weeks to induce Fe-deficiency anaemia. the rats were fed on day 35 a control diet, or a diet with 10% HP inulin, or a diet with 10% oligofructose, without Fe supplementation. the animals were euthanised after 2 weeks, and segments of the duodenum, caecum, colon and liver were removed. the expression levels of proteins in the intestinal segments were assessed using Western blotting. the levels of serum, urine and liver hepcidin ...
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