Risk factors for bloodstream infection in patients at a Brazilian hemodialysis center: a case-control study

Background: Infection is the leading cause of morbidity and the second leading cause of mortality in patients on renal replacement therapy. the rates of bloodstream infection in hemodialysis patients vary according to the type of venous access used. Gram- positive bacteria are most frequently isolated in blood cultures of hemodialysis patients. This study evaluated risk factors for the development of bloodstream infections in patients undergoing hemodialysis. Methods: Risk factors associated with bloodstream infections in patients on hemodialysis were investigated using a case- control study conducted between January 2010 and June 2013. Chronic renal disease patients on hemodialysis who presented with positive blood cultures during the study were considered as cases. Controls were hemodialysis patients from the same institution who did not present with positive blood cultures during the study period. Data were collected from medical records. Logistic regression was used for statistical analysis. Results: There were 162 patients included in the study (81 cases and 81 controls). Gram- positive bacteria were isolated with the highest frequency (72%). in initial logistic regression analysis, variables were hypertension, peritoneal dialysis with previous treatment, type and time of current venous access, type of previous venous access, previous use of antimicrobials, and previous hospitalization related to bloodstream infections. Multiple regression analysis showed that the patients who had a central venous catheter had an 11.2- fold (CI 95%: 5.17- 24.29) increased chance of developing bloodstream infections compared with patients who had an arteriovenous fistula for vascular access. Previous hospitalization increased the chance of developing bloodstream infections 6.6- fold (CI 95%: 1.9- 23.09). Conclusions: Infection prevention measures for bloodstream infections related to central venous catheter use should be intensified, as well as judicious use of this route for vascular access for hemodialysis. Reducing exposure to the hospital environment through admission could contribute to a reduction in bloodstream infections in this population.Universidade Federal de São Paulo, Paulista Sch Nursing, Sch Nursing, EPE UNIFESP, BR-04024002 São Paulo, BrazilUniv São Paulo ITACI FMUSP, Sch Med, Childrens Inst, Infect Control Unit, BR-05403000 São Paulo, BrazilUniv São Paulo ITACI FMUSP, Sch Med, Inst Treatment Childhood Canc, BR-05403000 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Nursing, EPM UNIFESP, Div Infect Dis,Escola Paulista Med, BR-04024002 São Paulo, BrazilFdn Oswaldo Ramos, HRIM FOR, Kidney & Hypertens Hosp, Div Dialysis, BR-04039030 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Nursing, Div Nephrol, EPM UNIFESP, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Nursing, Sch Nursing, EPE UNIFESP, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Nursing, EPM UNIFESP, Div Infect Dis,Escola Paulista Med, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Nursing, Div Nephrol, EPM UNIFESP, BR-04023900 São Paulo, BrazilWeb of Scienc