Secondary hyperparathyroidism and its relationship with sarcopenia in elderly women

Low dietary intake of calcium and poor vitamin D status during aging can result in mild secondary hyperparathyroidism, which may be associated with low muscle mass and reduced strength in the elderly. the aim of this study was to investigate whether low vitamin D, high parathormone (PTH), or both, are associated with sarcopenia. A total of 105 women, 35 with sarcopenia and 70 without sarcopenia, were enrolled in the present study. Body composition measurements were performed by DXA and sarcopenia was defined as skeletal muscle mass index 65 pg/dL) than in the absence of hyperparathyroidism (41.2 vs 16.2%, respectively; p = 0.046). the odds ratio for sarcopenia in hyperparathyroidism cases was 6.81 (95% CI 1.29-35.9) compared with participants who had low PTH and a high 25(OH) D concentration. the present study showed that vitamin D insufficiency associated with secondary hyperparathyroidism increased the risk of sarcopenia, suggesting that the suppression of hyperparathyroidism by ensuring adequate calcium and vitamin D intake should be considered in interventional studies to confirm potential benefits. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 São Paulo, BrazilUniversidade Federal de São Paulo, Div Rheumatol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Rheumatol, São Paulo, BrazilFAPESP: 03/06238-7FAPESP: 03/10314-0CNPq: 471213/2008-0Web of Scienc