Background: Our laboratory previously reported interesting rods 3-10 mu m long and rings 2-5 mu m diameter (RR) in the cytoplasm of mammalian cells. Experimental evidence show that both inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) and cytidine triphosphate synthetase (CTPS) are components of RR structures. Several cell types, including mouse embryonic stem cells, and cell lines, such as mouse 3 T3 and rat NRK, naturally present RR structures, while other cells can present RR when treated with compounds interfering with GTP/CTP biosynthetic pathways. in this study, we aimed to investigate the dynamic behavior of these RR in live cells.Results: RR were detected in > 90% of COS-7 and HeLa cells treated with 1 mM ribavirin or 6-Diazo-5-oxo...
Summary: Natural products have demonstrated utility in the clinic and can also act as probes to unde...
Inosine monophosphate dehydrogenase (IMPDH) catalyses the key step in de novo guanine nucleotide bio...
<div><p>We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzym...
<p>HeLa cells were either untransfected, transfected with siCTPS1, or siIMPDH2 for 44 h and followed...
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosph...
<p>Untreated HEp-2 cells (A) and cells treated with inhibitors 2 mM DON (CTPS inhibitor, B), 2 mM Ac...
AbstractFemale patient, complaining of weakness and pain in hypogastric, was admitted to the emergen...
"Rods and rings" (RR) and loukoumasomes are similarly shaped, subcellular macromolecular structures ...
SummaryInosine-5′-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in nucleotide biosyn...
Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guan...
Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, p...
<p>A. Western blots demonstrate a marked increase in nuclear IMPDH1 in Y79 cells treated with 1 mM r...
36 p.-6 fig.+inf. supl.18 p.-8 fig.-2 tab.Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes t...
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de ...
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de ...
Summary: Natural products have demonstrated utility in the clinic and can also act as probes to unde...
Inosine monophosphate dehydrogenase (IMPDH) catalyses the key step in de novo guanine nucleotide bio...
<div><p>We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzym...
<p>HeLa cells were either untransfected, transfected with siCTPS1, or siIMPDH2 for 44 h and followed...
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosph...
<p>Untreated HEp-2 cells (A) and cells treated with inhibitors 2 mM DON (CTPS inhibitor, B), 2 mM Ac...
AbstractFemale patient, complaining of weakness and pain in hypogastric, was admitted to the emergen...
"Rods and rings" (RR) and loukoumasomes are similarly shaped, subcellular macromolecular structures ...
SummaryInosine-5′-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in nucleotide biosyn...
Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guan...
Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, p...
<p>A. Western blots demonstrate a marked increase in nuclear IMPDH1 in Y79 cells treated with 1 mM r...
36 p.-6 fig.+inf. supl.18 p.-8 fig.-2 tab.Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes t...
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de ...
We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de ...
Summary: Natural products have demonstrated utility in the clinic and can also act as probes to unde...
Inosine monophosphate dehydrogenase (IMPDH) catalyses the key step in de novo guanine nucleotide bio...
<div><p>We recently reported that Inosine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzym...