Assessment of irradiated brain metastases using dynamic contrast-enhanced magnetic resonance imaging

The purpose of this study was to evaluate the effect of stereotactic radiosurgery (SRS) on cerebral metastases using the transfer constant (K (trans)) assessed by dynamic contrast-enhanced (DCE) MRI. Furthermore, we aimed to evaluate the ability of K (trans) measurements to predict midterm tumor outcomes after SRS.The study received institutional review board approval, and informed consent was obtained from all subjects. Twenty-six adult patients with a total of 34 cerebral metastases underwent T1-weighted DCE MRI in a 1.5-T magnet at baseline (prior to SRS) and 4-8 weeks after treatment. Quantitative analysis of DCE MRI was performed by generating K (trans) parametric maps, and region-of-interest-based measurements were acquired for each metastasis. Conventional MRI was performed at least 16 weeks after SRS to assess midterm tumor outcome using volume variation.The mean (+/- SD) K (trans) value was 0.13 +/- 0.11 min(-1) at baseline and 0.08 +/- 0.07 min(-1) after 4-8 weeks post-treatment (p < 0.001). the mean (+/- SD) total follow-up time was 7.9 +/- 4.7 months. Seventeen patients (22 lesions) underwent midterm MRI. of those, nine (41 %) lesions had progressed at the midterm follow-up. An increase in K (trans) after SRS was predictive of tumor progression (hazard ratio = 1.50; 95 % CI = 1.16-1.70, p < 0.001). An increase of 15 % in K (trans) showed a sensitivity of 78 % and a specificity of 85 % for the prediction of progression at midterm follow-up.SRS was associated with a reduction of K (trans) values of the cerebral metastases in the early post-treatment period. Furthermore, K (trans) variation as assessed using DCE MRI may be helpful to predict midterm outcomes after SRS.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ São Paulo, Dept Radiol, São Paulo, BrazilUniv Calif San Diego, Dept Radiol, San Diego, CA 92103 USAUniv Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USAUniv São Paulo, Dept Radiotherapy, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc