AimsDecorin and biglycan are members of the small leucine-rich proteoglycan family, and constituents of both the extracellular matrix (ECM) and the cell surface. They are recognized as important factors in the control of proliferation, migration and invasion invivo and invitro. in this study, the localization patterns of decorin and biglycan were determined in healthy placentas and in highly invasive placental pathologies.Methods and resultsThe study included immunolocalization of decorin and biglycan in samples of first-trimester and term placentas, placenta accreta, invasive mole, and choriocarcinoma. Extravillous cytotrophoblast (EVT) cells were positive for both proteoglycans in all pathologies and in first-trimester placentas, although...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Abstract Background We have previously demonstrated t...
Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-plac...
O decorim e o biglicam são membros da família dos pequenos proteoglicanos ricos em leucina e possuem...
Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structura...
Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structura...
Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis of which has been generall...
The human placenta is an invasive tumor-like structure, this invasion being physiological. A subset ...
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnanc...
The origin and regulation of stem cells sustaining trophoblast renewal in the human placenta remain ...
Preterm premature rupture of fetal membranes (PPROM) is associated with infection, and is one of the...
In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled wit...
Glycosaminoglycans (GAGs) are heteropolysaccharides in mammalian tissue and consist of repeated disa...
peer reviewedHuman placentation is a complex biological phenomenon that results from precisely regul...
Human placental villi are surfaced by the syncytiotrophoblast (STB), with a layer of cytotrophoblast...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Abstract Background We have previously demonstrated t...
Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-plac...
O decorim e o biglicam são membros da família dos pequenos proteoglicanos ricos em leucina e possuem...
Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structura...
Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structura...
Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis of which has been generall...
The human placenta is an invasive tumor-like structure, this invasion being physiological. A subset ...
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnanc...
The origin and regulation of stem cells sustaining trophoblast renewal in the human placenta remain ...
Preterm premature rupture of fetal membranes (PPROM) is associated with infection, and is one of the...
In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled wit...
Glycosaminoglycans (GAGs) are heteropolysaccharides in mammalian tissue and consist of repeated disa...
peer reviewedHuman placentation is a complex biological phenomenon that results from precisely regul...
Human placental villi are surfaced by the syncytiotrophoblast (STB), with a layer of cytotrophoblast...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Abstract Background We have previously demonstrated t...
Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-plac...