Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells
- Moraes-Vieira, Pedro M. M.
- Larocca, Rafael A.
- Bassi, Enio J.
- Peron, Jean Pierre S.
- Andrade-Oliveira, Vinicius
- Wasinski, Frederick
- Araújo, Ronaldo de Carvalho
- Thornley, Thomas
- Quintana, Francisco J.
- Basso, Alexandre Salgado
- Strom, Terry B.
- Câmara, Niels Olsen Saraiva
DOIAbstract
Leptin is an adipose-secreted hormone that plays an important role in both metabolism and immunity. Leptin has been shown to induce Th1-cell polarization and inhibit Th2-cell responses. Additionally, leptin induces Th17-cell responses, inhibits regulatory T (Treg) cells and modulates autoimmune diseases. Here, we investigated whether leptin mediates its activity on T cells by influencing dendritic cells (DCs) to promote Th17 and Treg-cell immune responses in mice. We observed that leptin deficiency (i) reduced the expression of DC maturation markers, (ii) decreased DC production of IL-12, TNF-, and IL-6, (iii) increased DC production of TGF-, and (iv) limited the capacity of DCs to induce syngeneic CD4(+) T-cell proliferation. As a conseque...
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