Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats

Sleep loss has been implicated in triggering the hypertension. the goal of the present study was investigated the possible mechanisms underlying cardiovascular alterations after acute paradoxical sleep deprivation (PSD). Male Wistar rats were assigned in two experimental groups: (1) control and (2) PSD for 24 h using the modified single platform method. Paradoxical sleep deprived rats exhibited higher blood pressure, heart rate (HR) and impaired baroreceptor sensitivity. After pharmacological autonomic double blockade (propranolol and methylatropine administration), intrinsic heart rate was decreased after PSD. the PSD rats showed a reduction in the vagal tone without affecting sympathetic tone. Isoproterenol administration (0.001, 0.01 and 1 mu g/kg) induced an increase in Delta HR responses in PSD group. Electrocardiographic analysis in response to beta-adrenergic stimulation indicated that PSD contributed to ventricular cardiac arrhythmias. Our findings suggest that acute paradoxical sleep loss induce cardiovascular alterations, autonomic imbalance accompanied by impaired baroreflex sensitivity and increased arrhythmia susceptibility.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, BR-04023060 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023060 São Paulo, BrazilUniv Fed Espirito Santo, EMESCAM, Dept Morphol, Vitoria, ES, BrazilFac Brasileira Med Sch, Vitoria, ES, BrazilUniversidade Federal de São Paulo, Dept Physiol, Div Cardiovasc, BR-04023060 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023060 São Paulo, BrazilCNPq: 558924/2008-5Web of Scienc