Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation

Studies of the effect of minor H antigen mismatching on the outcome of renal transplantation are scarce and concern mainly single center studies. the International Histocompatibility and Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large studies. in collaboration with 16 laboratories of the IHIW, the role of 15 autosomal, 10 Y-chromosome encoded minor H antigens and 3 CD31 polymorphisms, was investigated in relation to the incidence of renal graft rejection and graft loss in 444 human leukocyte antigens (HLA)-identical sibling renal transplantations. Recipient and donor DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, C19Orf48, LB-ECGF-1, CTSH, LRH-1, LB-ADIR and HY. the correlation between minor H antigen mismatch and the primary outcome graft rejection or graft loss was statistically analyzed. the incidence of rejection was very low and no correlation was observed between one or more minor H antigen mismatch(es) and a rejection episode (n=36), of which only eight resulted in graft loss. in summary, in our study cohort of 444 renal transplants, mismatching for neither autosomal nor HY minor H antigens correlate with rejection episodes or with graft loss.Netherlands Organization for Scientific Research (NWO)Macropa foundation15th International Histocompatibility and Immunogenetics Workshop SymposiumLeiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, NetherlandsUniv Med Ctr Utrecht, Dept Immunol, Utrecht, NetherlandsInst Diagnost & Referencia Epidemiol, Dept Immunol & Immunogenet, Mexico City, DF, MexicoInst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Transplantat, Mexico City, DF, MexicoCtr Inmunol Genet & Mol, Buenos Aires, DF, ArgentinaUniv Wisconsin, Dept Surg, Madison, WI USAUniversidade Federal de São Paulo, São Paulo, BrazilAssociacao Fundo Incent Pesquisa, São Paulo, BrazilMaastricht Univ, Med Ctr, Dept Nephrol, Maastricht, NetherlandsImmunol Trapianti Genet, Turin, ItalyCatholic Univ Louvain, Clin St Luc, B-1200 Brussels, BelgiumHosp Italiano Buenos Aires, Histocompatibil & Immunogenet ICBME, Buenos Aires, DF, ArgentinaSanquin Diagnost Serv, Amsterdam, NetherlandsInst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, MexicoCEMIC Ctr Educ Med & Invest Clin Norberto Quirno, Histocompatibil Lab, Buenos Aires, DF, ArgentinaIstanbul Univ, Istanbul Fac Med, Dept Med Biol, Istanbul, TurkeyHeidelberg Univ, Inst Immunol, Heidelberg, GermanyImperial Coll Healthcare NHS Trust, London, EnglandMaastricht Univ, Med Ctr, Tissue Typing Lab, Maastricht, NetherlandsErasmus MC, Rotterdam, NetherlandsUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc