Chemical constituents derived from Drimys brasiliensis Miers (Winteraceae)

Phytochemical investigation on Drimys brasiliensis afforded the isolation and characterisation of four drimane sesquiterpenes: polygodial (1), warburganal (2), 1--(p-coumaroyloxy)polygodial (3) and 1--(p-methoxycinnamoyl)polygodial (4), as well as four flavonoids: quercitrin (5), astilbin (6), isoastilbin (7) and neoastilbin (8). the structures were elucidated on the basis of their spectral data and compared with those reported in the literature. Compounds 2, 5-8 have been reported to occur for the first time in D. brasiliensis, while compounds 5, 7 and 8 have been reported to occur for the first time in the genus Drimys. the chemotaxonomic significance of these compounds, mainly flavonoids 5-8 in D. brasiliensis, was summarised.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, BrazilWeb of Scienc