Histologic and histomorphometric evaluation of a synthetic bone substitute for maxillary sinus grafting in humans

Objective: the present study investigated the efficacy of a biphasic calcium phosphate as a bone grafting material for maxillary sinus augmentation in humans.Materials and methods: Half of the thirty patients selected for sinus augmentation were grafted with biphasic calcium phosphate, whereas the other half were grafted with autogenous bone chips harvested intraorally. After 9 months of healing, bone cores were retrieved from implant sites for histologic and histomorphometric evaluation.Results: the areas augmented with autogenous bone chips showed newly formed bone with a pattern very similar to that of the native area. Histomorphometry demonstrated that the amount of newly formed bone in the autogenous bone group was significantly greater than in the biphasic calcium phosphate group (P < 0.05). in the biphasic calcium phosphate group, less bone formation was observed in the area further away from native bone interface than in the area closer to native bone interface (P < 0.05), whereas no significant differences were observed between both areas in the autogenous group. in both groups, the implant survival rate was 100% with a minimum 1-year follow-up.Conclusion: the data presented in this work confirm the osteoconductive properties of biphasic calcium phosphate, as well as its use in association with maxillary sinus floor augmentation procedures with successful outcomes.CETAO, Inst Hlth Res, Dept Oral Implantol, BR-03323000 São Paulo, BrazilUniv São Paulo, Dept Stomatol, Sch Dent, BR-05508 São Paulo, BrazilUniv São Paulo, Dept Oral Pathol, Sch Dent, BR-05508 São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Morphol, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Morphol, São Paulo, BrazilWeb of Scienc