Effects of low-level laser therapy on the expression of osteogenic genes related in the initial stages of bone defects in rats
- Fernandes, Kelly Rossetti
- Ribeiro, Daniel Araki
- Rodrigues, Natalia Camargo
- Tim, Carla
- Santos, Anderson Amaro
- Parizotto, Nivaldo Antonio
- Araujo, Heloisa Selistre de
- Driusso, Patricia
- Renno, Ana Claudia Muniz
DOIAbstract
We evaluate the effects of low-level laser therapy (LLLT) on the histological modifications and temporal osteogenic genes expression during the initial phase of bone healing in a model of bone defect in rats. Sixty-four Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 0.028 cm(2), 1.071 W/cm(2), 1 min and 34 s, 2.8 Joules, 100 J/cm(2)) was performed for 1, 2, 3, and 5 sessions. Histopathology revealed that treated animals presented higher inflammatory cells recruitment, especially 12 and 36 h postsurgery. Also, a better tissue organization at the site of the injury, with the presence of granulation...
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