Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance

The prevention of obesity and health concerns related to body fat is a major challenge worldwide. the aim of this study was to investigate the role of a medically supervised, multidisciplinary approach, on reduction in the prevalence of obesity related comorbidities, inflammatory profile, and neuroendocrine regulation of energy balance in a sample of obese adolescents. A total of 97 postpuberty obese adolescents were enrolled in this study. Body composition, neuropeptides, and adipokines were analysed. the metabolic syndrome was defined by the International Diabetes Federation (IDF). the abdominal ultrasonography was performed to measure visceral, subcutaneous fat and hepatic steatosis. All measures were performed at baseline and after one year of therapy. the multidisciplinary management promoted the control of obesity reducing body fat mass. the prevalence of metabolic syndrome, asthma, nonalcoholic fatty liver disease (NAFLD), binge eating, and hyperleptinemia was reduced. An improvement in the inflammatory profile was demonstrated by an increase in anti-inflammatory adiponectin and reduction in proinflammatory adipokines, plasminogen activator inhibitor-1, interleukin-6 concentrations, and in the Lep/Adipo ratio. Moreover, a reduction in the AgRP and an increase in the alfa-MSH were noted. the multidisciplinary approach not only reduced obesity but also is efficacious in cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance.CEPEFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)AFIPConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FADACoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São PauloUniversidade Federal de São Paulo UNIFESP, Dept Biosci, BR-11015020 Santos, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Postgrad Program Nutr, BR-04020060 São Paulo, BrazilObes Rehabil Ctr INSULA, Insulaweg, Bischofswiesen, GermanyUniversidade Federal de São Paulo UNIFESP, Dept Physiol, BR-04021001 São Paulo, BrazilWeight Sci, BR-05406000 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04021001 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Biosci, BR-11015020 Santos, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Postgrad Program Nutr, BR-04020060 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Physiol, BR-04021001 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04021001 São Paulo, BrazilFAPESP: 2006/00684-3FAPESP: 2008/53069-0FAPESP: 2011/503560FAPESP: 2011/50414-0FAPESP: 9814303-3CAPES: 2566/2011Web of Scienc