Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

Conclusion: We conclude that facial nerve injury induced by compression is associated with a reasonable time window (4 weeks) that allows possible neurotrophic effects to be analyzed. Additionally, there are no hints of cross-innervation by the contralateral facial nerve or parallel innervation by other nerves in the hemiface ipsilateral to the injured nerve. Objective: the aim of this work was to develop an experimental model of facial nerve injury in nonhuman primates (Callithrix sp.). Methods: in this study, individuals of the non-human primate species Callithrix sp. were subjected to three different types of facial nerve injury, and they were observed for 27 days after surgery by video to record their facial movements. Results: Two types of nerve compression caused severe initial facial paralysis followed by gradual recovery until normal levels were reached at the end of the evaluation period. Injury induced by nerve resection was followed by a complete lack of facial movement recovery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fed Univ São Paulo UNIFESP, Otorhinolaryngol & Head & Neck Surg Dept, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Physiol, São Paulo, BrazilFed Univ São Paulo UNIFESP, Otorhinolaryngol & Head & Neck Surg Dept, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Physiol, São Paulo, BrazilFAPESP: FAPESP 2009/52805-7Web of Scienc