A novel bioactive vitroceramic presents similar biological responses as autogenous bone grafts

Bioactive glasses represent an interesting class of bone substitute's biomaterials. the present study investigated the repair of bone defects filled with a novel bioactive vitroceramic (Biosilicate(A (R))), alone or in association with particulate autogenous bone grafts in calvaria defects of rabbits. After 7, 14, and 30 days the specimens were retrieved for histological, histomorphometric and immunohistochemistry analysis. Satisfactory bone formation was observed in all groups, and direct bone-biomaterial surface was noted. Histomorphometric assessment did not show statistically significant differences in bone formation among the groups and periods, except for BG group at day 14. Immunoexpression of Runx-2 was similar among the groups containing the graft and the biomaterial, being more intense than in control group. Similar result was observed for VEGF expression, especially in the last experimental period. These results revealed that Biosilicate(A (R)) presented a favorable behavior, comparable to autogenous bone graft.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sagrado Coracao, Dept Hlth Sci, Discipline Oral & Maxillofacial Surg, BR-17013070 Bauru, SP, BrazilUniv Sagrado Coracao, Sch Dent, BR-17011160 Bauru, SP, BrazilUniv Sagrado Coracao, Dept Hlth Sci, Discipline Oral & Maxillofacial Surg, BR-17011160 Bauru, SP, BrazilUniv Sagrado Coracao, Dept Hlth Sci, Discipline Periodontol, BR-17011160 Bauru, SP, BrazilUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, BrazilUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, BrazilFAPESP: 2008/11485-8FAPESP: 2009/17294-1Web of Scienc