Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. the device presents relevant advantages such as direct determination-dismiss the use of redox mediators as in faradaic electrochemical techniques-and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Centro Nacional de Pesquisa em Energia e Materiais (CNPEM)Centro de Caracterizacao e Desenvolvimento de Materiais (CCDM)Universidade Federal de São Paulo, Inst Quim Sao Carlos, Sao Carlos, SP, BrazilInst Nacl Ciencia & Tecnol Bioanalit, Campinas, SP, BrazilCtr Nacl Pesquisa Energia & Mat, Lab Nacl Nanotecnol, Campinas, SP, BrazilUniv Fed Sao Carlos, Dept Mat Engn, BR-13560 Sao Carlos, SP, BrazilUniv Fed Goias, Inst Quim, Goiania, Go, BrazilUniversidade Federal de São Paulo, Inst Quim Sao Carlos, Sao Carlos, SP, BrazilFAPESP: 2008/07597-4FAPESP: 2010/08559-9Web of Scienc