Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation

Uveitis is an intraocular inflammatory disease causing a significant visual impairment. the disease can be idiopathic, associated with infectious and systemic disorders or arisen from an unknown cause. Over the last 20 years the model of EAU in mice has contributed significantly for the establishment of parameters for diagnostic evaluations and therapies for posterior uveitis in human. Many studies using recently discovered molecules which present proinflammatory and anti-inflammatory effects have been described. Moreover, new approaches of research provided by the increasing body of knowledge on components of immune responses such as cytokines, 1-cell subpopulations and their associated functions have contributed for the further understanding of uveitis and possible treatment. (C) 2010 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Hosp Israelita Albert Einstein, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFFSP, Vis Inst, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFFSP, Div Immunol, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFFSP, Vis Inst, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFFSP, Div Immunol, São Paulo, BrazilCAPES: 4056/09-4Web of Scienc