Influence of genotype on dopamine transporter availability in human striatum and sleep architecture

Genetic variants may modulate dopamine transporter (DAT) availability in the brain. A polymorphism within the intron 8 of the DAT1 gene was evaluated in 27 healthy men. No correlation between Int8 VNTR and either the inter-individual variability of the sleep architecture, or the DAT availability, as measured by single photon emission computed tomography (SPECT) and [(99m)Tc]TRODAT-1 was observed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04021002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Escola Paulista Med, LiNC, BR-04021002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04021002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Escola Paulista Med, LiNC, BR-04021002 São Paulo, BrazilFAPESP: 98/14303-3Web of Scienc