Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained beta-adrenergic hyperactivity
- Serra, Andrey J.
- Santos, Marilia H. H.
- Bocalini, Danilo S.
- Antonio, Ednei L.
- Levy, Rozeli F.
- Santos, Alexandra A.
- Higuchi, Maria L.
- Silva, Jose A.
- Magalhaes, Flavio C.
- Barauna, Valerio G.
- Krieger, Jose E.
- Tucci, Paulo J. F.
DOIAbstract
Myocardial hypertrophy and dysfunction occur in response to excessive catecholaminergic drive. Adverse cardiac remodelling is associated with activation of proinflammatory cytokines in the myocardium. To test the hypothesis that exercise training can prevent myocardial dysfunction and production of proinflammatory cytokines induced by beta-adrenergic hyperactivity, male Wistar rats were assigned to one of the following four groups: sedentary non-treated (Con); sedentary isoprenaline treated (Iso); exercised non-treated (Ex); and exercised plus isoprenaline (Iso+Ex). Echocardiography, haemodynamic measurements and isolated papillary muscle were used for functional evaluations. Real-time RT-PCR and Western blot were used to quantify tumour ne...
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