Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology
- Grinberg, Lea Tenenholz
- Amaro Junior, Edson
- Silva, Alexandre Valotta da
- Silva, Rafael Emidio da
- Sato, Joao Ricardo
- Santos, Denis Dionizio dos
- Pacheco, Silmara de Paula
- Lucena Ferretti, Renata Eloah de
- Paraizo Leite, Renata Elaine
- Pasqualucci, Carlos Augusto
- Teipel, Stefan J.
- Flatz, Wilhelm H.
- Heinsen, Helmut
- Brazilian Aging Brain Study Grp
DOIAbstract
The histopathological counterpart of white matter hyperintensities is a matter of debate. Methodological and ethical limitations have prevented this question to be elucidated.We want to introduce a protocol applying state-of-the-art methods in order to solve fundamental questions regarding the neuroimaging-neuropathological uncertainties comprising the most common white matter hyperintensities [WMHs] seen in aging. By this protocol, the correlation between signal features in in situ, post mortem MRI-derived methods, including DTI and MTR and quantitative and qualitative histopathology can be investigated. We are mainly interested in determining the precise neuroanatomical substrate of incipient WMHs. A major issue in this protocol is the ex...
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