Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known regarding their exact roles in epileptogenesis. Temporal-lobe epilepsy (TLE) in rat was induced by pilocarpine in order to study changes of hippocampal P2X(2), P2X(4) and P2X(7) receptor expression during acute, latent or chronic phases of epilepsy. During acute and chronic phases increased P2X(7) receptor expression was principally observed in glial cells and glutamatergic nerve terminals, suggesting participation of this receptor in the activation of inflammatory and excitotoxic processes during epileptogenesis. No significant alterations of hippocampal P2X(2) and P2X(4) receptor expression was noted during the acute or latent phase when comp...
CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PE...
Current pharmacological approaches to treat epilepsy are mainly focused on enhancing neuronal inhibi...
Epilepsy is a common and disabling neurologic disease characterized by the occurrence of recurrent, ...
Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known re...
Purpose: This study was performed to study the role of adenosine triphosphate (ATP) in the brain of ...
The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively exp...
Epilepsy is one of the most common chronic neurological diseases and is characterized by recurrent s...
Abstract: In the central nervous system (CNS), ATP is released from vesicles at nerve terminals in a...
Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epil...
Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a sta...
Despite the progress made in the development of new antiepileptic drugs (AEDs), the biggest challeng...
International audienceUntil recently, analysis of the mechanisms underlying epilepsy was centered on...
Thirty percent of the adult population with epilepsy is resistant to commercially available anti-sei...
Epilepsy is a common and devastating neurological disorder characterised by increased and abnormal n...
AIMS: Early-life seizures, particularly when prolonged, may be harmful to the brain. Current pharmac...
CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PE...
Current pharmacological approaches to treat epilepsy are mainly focused on enhancing neuronal inhibi...
Epilepsy is a common and disabling neurologic disease characterized by the occurrence of recurrent, ...
Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known re...
Purpose: This study was performed to study the role of adenosine triphosphate (ATP) in the brain of ...
The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively exp...
Epilepsy is one of the most common chronic neurological diseases and is characterized by recurrent s...
Abstract: In the central nervous system (CNS), ATP is released from vesicles at nerve terminals in a...
Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epil...
Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a sta...
Despite the progress made in the development of new antiepileptic drugs (AEDs), the biggest challeng...
International audienceUntil recently, analysis of the mechanisms underlying epilepsy was centered on...
Thirty percent of the adult population with epilepsy is resistant to commercially available anti-sei...
Epilepsy is a common and devastating neurological disorder characterised by increased and abnormal n...
AIMS: Early-life seizures, particularly when prolonged, may be harmful to the brain. Current pharmac...
CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PE...
Current pharmacological approaches to treat epilepsy are mainly focused on enhancing neuronal inhibi...
Epilepsy is a common and disabling neurologic disease characterized by the occurrence of recurrent, ...