From Mono- to Poly-Substituted Frameworks: A Way of Tuning the Acidic Character of C-c-H in o-Carborane Derivatives

[EN] The incorporation of iodine atoms onto the boron vertices of the o-carborane framework causes, according to spectroscopic data, a uniform increase in the acidic character of the C-c-H (C-c= cluster carbon) vertices, whereas the incorporation of methyl groups onto the boron vertices of the o-carborane framework reduces their acidity. Methyl groups when attached to boron are electron-withdrawing in boron clusters, whereas iodine atoms bonded to boron act as electron donors. This has been proven on B-methyl and B-iodinated o-carboranes with NMR spectroscopy measurements and DFT calculations of natural bond orbital (NBO) charges. which show a Cumulative buildup of positive cluster only total charge (CTC) on B-methyl o-carboranes and a cumulative buildup of negative cluster-only total charge for B-iodinated o-carboranes.This work was supported by CICYT (project MAT2006-05339), Generalitat de Catalunya (2005/SGR/00709).Puga, AV.; Teixidor, F.; Sillanpaa, R.; Kivekas, R.; Arca, M.; Barbera, G.; Viñas, C. (2009). From Mono- to Poly-Substituted Frameworks: A Way of Tuning the Acidic Character of C-c-H in o-Carborane Derivatives. Chemistry - A European Journal. 15(38):9755-9763. doi:10.1002/chem.200900925S97559763153