Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models

Several species of the genus Passiflora, known in Brazil as 'maracuja', have widespread use in folk medicine as sedatives and anxiolytics. the anxiolytic activities of aqueous and hydroalcohol extracts of Passiflora quadrangularis leaves were evaluated using the elevated plus-maze, open held and holeboard tests. the hydroalcohol extract presented results suggestive of anxiolytic activity in dosages around 100, 250 and 500 mg/kg, as expressed by elevation of the time spent on the open arms in the plus-maze; a decrease of freezing and an increase of deambulation and rearing in the open field lest. the hydroalcohol extract showed results similar to diazepam on the holeboard. No positive results were found for the aqueous extract. Copyright (c) 2007 John Wiley & Sons, Ltd.Universidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilCESUPA, Lab Phytochem, Belem, Para, BrazilUEPA, Pharmacol Lab, Belem, Para, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of Scienc