Reference intervals for the cross sectional area of the umbilical cord during gestation

Objective: To establish reference values for the sonographic cross-sectional area of the umbilical cord during gestation and to correlate them with fetal anthropornetric parameters.Methods: A cross-sectional study was performed involving 312 normal pregnant women at gestational ages 2439 weeks. Measurement of the cross-sectional area of umbilical cord was performed on a plane adjacent to the insertion of the cord into fetal abdomen. the following anthropometric parameters were calculated: biparietal diameter, head circumference, abdominal circumference and femur length. A polynomial regression analysis identified the curves that were better adjusted to the average and standard deviation according to gestational age. Spearman correlation was used to evaluate the correlation of the cross-sectional area of umbilical cord with fetal anthropometric parameters.Results: A statistically significant correlation was observed between the cord cross-sectional area and gestational age (r = 0.376, P < 0.001, CI 95% [0.276; 0.467]).Conclusions: the reference values of the cross-sectional area of umbilical cord increased according to gestational age until the 33(rd) week and are related to parameters of fetal growth.Universidade Federal de São Paulo, Unifesp, EPM, Dept Obstet, São Paulo, BrazilUniversidade Federal de São Paulo, Unifesp, EPM, Dept Obstet, São Paulo, BrazilWeb of Scienc