Diagnosis of paracoccidioidomycosis by detection of antigen and antibody in bronchoalveolar lavage fluids

Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis and is believed to be the leading cause of fungal pulmonary infection. in this study, we used an inhibition enzyme-linked immunosorbent assay to diagnose pulmonary PCM based on the detection of 43-kDa and 70-kDa molecules in bronchoalveolar lavage fluids. the results were compared with results obtained by classical methods for antibody detection.Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilUniv Estadual Campinas, Dept Clin Pathol, Sch Med, Campinas, SP, BrazilUniv Estadual Campinas, Dept Internal Med, Sch Med, Campinas, SP, BrazilUniv Fed Parana, Sch Med, Dept Community Hlth, BR-80060000 Curitiba, Parana, BrazilUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilWeb of Scienc