Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa

Objectives: To evaluate relationships between the inflammatory response, clinical. course, and outcome of nosocomial. BSI due to Pseudomonas aeruginosa.Methods: We performed a historical cohort study on 77 adults with P. aeruginosa (Pa) nBSI to define the associated systemic inflammatory response syndrome (SIRS). We examined SIRS scores 2 days prior through 14 days after the first positive blood culture. Imipenem resistant-IRPa (n=20) and susceptible infections-ISPa (n=57) were compared. Variables significant in univariate analysis were entered into a logistic regression model.Results: Seventy-four percent of BSI were ISPa and 26.0% by IRPa. Septic shock occurred in 39.0%. Crude mortatity was 48.1%. There was no difference in APACHE II (AP2) scores on days -2, -1 and 0 between the ISPa and IRPa groups. Multivariate analysis revealed that AP2 >= 20 at BSI onset (P