Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents
- Coplan, P. M.
- Gupta, S. B.
- Dubey, S. A.
- Pitisuttithum, P.
- Nikas, A.
- Mbewe, B.
- Vardas, E.
- Schechter, M.
- Kallas, Esper Georges
- Freed, D. C.
- Fu, T. M.
- Mast, C. T.
- Puthavathana, P.
- Kublin, J.
- Collins, K. B.
- Chisi, J.
- Pendame, R.
- Thaler, S. J.
- Gray, G.
- Mcintyre, J.
- Straus, W. L.
- Condra, J. H.
- Mehrotra, D. V.
- Guess, H. A.
- Emini, E. A.
- Shiver, J. W.
DOIAbstract
Background. the genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades.Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-gamma enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the Un...
Add to ORKG