Relationship between gene polymorphisms and prevalence of myocardial infarction among diabetic and non-diabetic subjects

This study was aimed to examine cholesteryl ester transfer protein (CETP). apolipoprotein AI and CIII gene polymorphisms. and to verify whether these genetic determinants are associated with the prevalence of myocardial infarction (MI) or type 2 diabetes. the TaqIB restriction fragment length polymorphism (RFLP) in intron I of the CETP gene. the Mspl in the third intron of the APOAI gene. and also Ssrl in the 3' untranslated region of the APOCIII gene were determined using standard methods. the prevalence of these, polymorphisms was compared between diabetic (n = 119), and non-diabetic (n = 100) middle-aged individuals of both sexes. We found a higher prevalence of the B2B2 genotype of the CETP gene among diabetics than that observed in non-diabetics (P < 0.05), and a lower prevalence of this genotype among patients with previous MI (P < 0.02). the Mspl polymorphisms of the APOA1 gene showed that M1 divided by divided by genotype was found mainly in diabetic patients (P < 0.04). Conversely, the SstI polymorphism of APOCIII gene was not significantly associated with either MI or diabetes. Therefore, among these genetic polymorphisms. TaqIB of CETP and Mspl of apolipoprotein AI appeared to help significantly to identify diabetic individuals. in particular, the former may have an additional role in the primary prevention of coronary disease. (C) 2004 Elsevier Ireland Ltd. All rights reserved.Universidade Federal de São Paulo, UNIFESP, Disciplina Cariol, BR-04039001 São Paulo, BrazilUniversidade Federal de São Paulo, UNIFESP, Disciplina Cariol, BR-04039001 São Paulo, BrazilWeb of Scienc