An outbreak of mycobacterium chelonae infection after LASIK

Objective: To describe an outbreak of mycobacterial keratitis after laser in situ keratomileusis (LASIK), including the microbiologic investigation, clinical findings, treatment response, and outcome.Design: Retrospective, noncomparative, interventional case series.Participants: Patients (n = 10) who underwent LASIK surgery between August 22 and September 4, 2000, and developed mycobacterial infection.Methods: Patients were prospectively followed in relation to microbiologic investigation, clinical findings, treatment response, and outcome.Main Outcome Measures: Most patients underwent bilateral simultaneous LASIK. Postoperative infection was signaled by the appearance of corneal infiltrates in the third postoperative week. the microbiologic workup was performed on cultures obtained either by direct scraping of the cornea or by lifting the flap. Medical therapy was instituted based on drug susceptibility testing. Surgical interventions such as corneal debridement and flap removal were performed during recurrences or when there was no satisfactory clinical response.Results: Cultures revealed Mycobacterium subspecies chelonae. Patients were treated with topical clarithromycin (1%), tobramycin (1.4%), and ofloxacin (0.3%). Oral clarithromycin (500 mg twice a day) was prescribed for those patients who did not respond clinically to topical treatment. Four eyes healed on this regimen. Flap removal was necessary in seven eyes.Conclusions: This report highlights mycobacteria as an etiologic infectious agent after LASIK. Diagnosis can be difficult and is often delayed. the treatment mainstay is prolonged antibiotic therapy. Surgical debridement and flap removal may shorten the disease course. (C) 2003 by the American Academy of Ophthalmology.Universidade Federal de São Paulo, São Paulo Hosp, Paulista Sch Med, Dept Ophthalmol, BR-04023062 São Paulo, BrazilFleury Labs Inc, São Paulo, BrazilUniv Calif Davis, Dept Ophthalmol, Davis, CA 95616 USAUniversidade Federal de São Paulo, São Paulo Hosp, Paulista Sch Med, Dept Ophthalmol, BR-04023062 São Paulo, BrazilWeb of Scienc