EFFECT of VALEPOTRIATES ON the BEHAVIOR of RATS in the ELEVATED PLUS-MAZE DURING DIAZEPAM WITHDRAWAL

Andreatini, R.
LEITE, JR

Open link

Publication date

August 1994

DOI

10.1016/0014-2999(94)90342-5

Publisher

Elsevier BV

ISSN

0014-2999

Journal

European Journal of Pharmacology

Citation count (estimate)

Abstract

The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. the rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. the abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.ESCOLA PAULISTA MED,DEPT PSICOBIOL,BR-04023062 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT PSIC...