Symptomatic cardiac involvement in juvenile rheumatoid arthritis

In a retrospective study of 172 patients with juvenile rheumatoid arthritis, symptomatic cardiac involvement occurred in 13 (7.6%) patients (11 systemic and 2 polyarticular). There was predominance of the male sex and in most patients the involvement occurred in the initial years of the disease. Pericarditis occurred in seven patients; perimyocarditis in four and myocarditis in two patients. in the follow-up, one of the patients with pericarditis died of an arrhythmia during pericardiocentesis for cardiac tamponade. Among the patients with myocarditis, three died of septicemia during active disease. One of these three patients had myocarditis associated with cardiac tamponade. Among the 172 patients with juvenile rheumatoid arthritis, five children died; four belonged to the symptomatic cardiac involvement group (P < 0.001). Cardiac involvement, in particular myocarditis and cardiac tamponade, can be regarded as a factor of worse prognosis.ESCOLA PAULISTA MED SCH,DEPT MED,DIV CARDIOL & RHEUMATOL,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT PEDIAT,DIV ALLERGY IMMUNOL & RHEUMATOL,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT MED,DIV CARDIOL & RHEUMATOL,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT PEDIAT,DIV ALLERGY IMMUNOL & RHEUMATOL,BR-04023 São Paulo,BRAZILWeb of Scienc