Metabolic changes of several adipose depots as caused by aging

Ursini, F.
Vugman, M.
Fernandes, L. C.
Nascimento, Claudia Maria da Penha Oller do
Curi, Rui

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Publication date

August 1991

DOI

10.1016/0031-9384(91)90072-V

Publisher

Elsevier BV

ISSN

0031-9384

Journal

Physiology & Behavior

Abstract

In this study, metabolic changes of several adipose depots as caused by aging were investigated. Key enzyme activity of glutaminolysis, pentose-phosphate pathway and Krebs cycle were measured. the rates of lipogenesis from (H2O)-H-3, lipoprotein lipase (LPL) activity and rate of lipolysis in vitro were also determined. the results obtained indicate a reduced capacity for lipogenesis in several adipose depots by aging. the authors concluded that hypertrophy of adipose tissue reported during aging is possible due to increased LPL activity and reduced rate of lipolysis.ESCOLA PAULISTA MED SCH,DEPT PHYSIOL,RUA BOTUCATU,862-2 ANDAR,BR-04023 São Paulo,BRAZILSão Paulo UNIV,INST BIOMED SCI,DEPT PHYSIOL & BIOPHYS,BR-05508 BUTIANTRAN,SP,BRAZILESCOLA ...