Role anti-inflammatory of adiponectin and interleukin-10 in obesity model clinical and experimental

Objective: The purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA, and endotoxin level and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy. Design: The present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n=18, aged 15-19 y) with a body mass index > 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. In addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMAIR). Results: The most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR (p<0.05). In addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR (p<0.05). Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels (p