Does the change on gastrointestinal tract microbiome affects host?

During the past decade, studies on the composition of human microbiota and its relation to the host became one of the most explored subjects of the medical literature. The development of high-throughput molecular technologies allowed a deeper characterization of human microbiota and a better understanding of its relationship with health and disease. Changes in human habits including wide use of antimicrobials can result in dysregulation of host–microbiome homeostasis, with multiple consequences. The purpose of this review is to highlight the most important evidence in the literature of host–microbiome interactions and illustrate how these intriguing relations may lead to new treatment and prevention strategies.Hospital Heliópolis Department of InfectiologyUniversidade Federal de São Paulo (UNIFESP) Disciplina de Infectologia Micology Special LaboratoryUniversidade Federal de São Paulo (UNIFESP) Disciplina de Infectologia Service of Hospital Infection ControlUNIFESP, Disciplina de Infectologia Micology Special LaboratoryUNIFESP, Disciplina de Infectologia Service of Hospital Infection ControlSciEL