The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock

Freitas, Flavio Geraldo Rezende
Salomão, Reinaldo
Tereran, Nathalia
Mazza, Bruno Franco
Assunção, Murillo
Jackiu, Mirian
Fernandes, Haggeas
Machado, Flávia Ribeiro

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Publication date

January 2008

DOI

10.1590/S1807-59322008000400012

Publisher

FapUNIFESP (SciELO)

Journal

Clinics

Abstract

OBJECTIVES: This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock. METHODS: Clinical data were collected from hospital charts of patients with severe sepsis and septic shock admitted to a mixed intensive care unit from November 2003 to February 2004. The duration of organ dysfunction prior to diagnosis was correlated with mortality. Results were considered significant if p<0.05. RESULTS: Fifty-six patients were enrolled. Mean age was 55.6 ± 20.7 years, mean APACHE II score was 20.6 ± 6.9, and mean SOFA score was 7.9 ± 3.7. Thirty-six patients (64.3%) had septic shock. The mean duration of organ dysfunction was 1.9 ± 1.9 days. Within the univariate analysis, t...