Occurrence of the alcoholic tolerance phenomenon and their relationships with daily frequency of ethanol doses and with the presence of an withdrawal interval, in an experimental model of alcoholism in rats

In this paper we present the effects of the number of daily toxic doses of alcohol and of the duration of withdrawal period on alcohol tolerance in rats submitted to cycles of 21 doses each. It was observed that alcohol tolerance was increased in animals which received less number of alcohol doses by day and that some degree of tolerance can be detected even after a withdrawal interval of 15 days.Os autores apresentam os resultados de estudo sobre as influências do número diário de doses intoxicantes da droga e da presença de intervalo de abstinência, sobre a tolerância alcoólica em ratos submetidos a ciclos de 21 doses. Observou-se que o aumento da tolerância foi mais acentuado nos animais que receberam menor número diário de doses, e que certo grau de tolerância pode ser detectado após um intervalo de abstinência de 15 dias.Escola Paulista de Medicina Laboratório de Neurologia Experimental, Disciplina de Neurologia ClínicaUNIFESP, EPM, Laboratório de Neurologia Experimental, Disciplina de Neurologia ClínicaSciEL