The convulsant alkaloid strychnine is a selective and highly potent antagonist at postsynaptic receptor for the inhibitory neurotransmitter glycine. These properties have led to the extensive use of strychnine as a ligand to probe the postsynaptic glycine receptor. Despite the recent increased understanding of the molecular structure of this receptor protein there is still much dispute as to the nature of the interaction between glycine and strychnine. In an attempt to more clearly define this interaction the experiments described, combine the techniques of protein modification and ligand binding. These investigations also revealed a novel [3H]-strychnine binding site in the rodent CNS and attempts were made to characterize this phenomenon....
The purpose of this work was to define the pharmacology of an intestinal epithelial [3H]strychnine b...
In this review we provide an overview of key in vivo experiments, undertaken in the cat spinal cord ...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...
Interactions between the inhibitory neurotransmitter glycine and its receptor antagonist strychnine ...
The inhibitory glycine receptors are one of the major mediators of rapid synaptic inhibition in the ...
THE excitatory action of strychnine on the central nervous system results from its ability to antago...
Polyclonal antibodies have been raised in rabbits against the glycine receptor antagonist strychnine...
Recent evidence suggests that a strychnine-insensitive glycine modulatory site is associated with th...
trychnine was coupled to fluorescein isothiocyanate to mark strychnine binding sites in spinal cord ...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
peer reviewedStrychnos icaja Baill. (Loganiaccae) is a liana found in Central Africa known to be an ...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
textThe inhibitory glycine receptor is a target for both alcohols and volatile anesthetics. The func...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
Specific [3H]strychnine binding was used to identify the glycine receptor macromolecular complex in ...
The purpose of this work was to define the pharmacology of an intestinal epithelial [3H]strychnine b...
In this review we provide an overview of key in vivo experiments, undertaken in the cat spinal cord ...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...
Interactions between the inhibitory neurotransmitter glycine and its receptor antagonist strychnine ...
The inhibitory glycine receptors are one of the major mediators of rapid synaptic inhibition in the ...
THE excitatory action of strychnine on the central nervous system results from its ability to antago...
Polyclonal antibodies have been raised in rabbits against the glycine receptor antagonist strychnine...
Recent evidence suggests that a strychnine-insensitive glycine modulatory site is associated with th...
trychnine was coupled to fluorescein isothiocyanate to mark strychnine binding sites in spinal cord ...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
peer reviewedStrychnos icaja Baill. (Loganiaccae) is a liana found in Central Africa known to be an ...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
textThe inhibitory glycine receptor is a target for both alcohols and volatile anesthetics. The func...
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or in...
Specific [3H]strychnine binding was used to identify the glycine receptor macromolecular complex in ...
The purpose of this work was to define the pharmacology of an intestinal epithelial [3H]strychnine b...
In this review we provide an overview of key in vivo experiments, undertaken in the cat spinal cord ...
Strychnine−sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brain...