Computer simulation of flagellar movement X: Doublet pair splitting and bend propagation modeled using stochastic dynein kinetics

  • Brokaw, Charles J.
Publication date
April 2014
Publisher
Royal College of Obstetricians & Gynaecologists (RCOG)

Abstract

Experimental observations on cyclic splitting and bending by a flagellar doublet pair are modeled using forces obtained from a model for dynein mechanochemistry, based on ideas introduced by Andrew Huxley and Terrill Hill and extended previously for modeling flagellar movements. The new feature is elastic attachment of dynein to the A doublet, which allows movement perpendicular to the A doublet and provides adhesive force that can strain attached dyneins. This additional strain influences the kinetics of dynein attachment and detachment. Computations using this dynein model demonstrate that very simple and realistic ideas about dynein mechanochemistry are sufficient for explaining the separation and reattachment seen experimentally with fl...

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