Add to ORKGGiven the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...
With the recent successes in determining membrane protein structures, we explore the tractability of...
Abstract: Transmembrane proteins allow cells to extensively communicate with the external world in a...
Background: Membrane proteins are key components in a large spectrum of diverse functions and thus a...
Membrane proteins serve as cellular gatekeepers, regulators, and sensors. Prior studies have explore...
Abstract Membrane proteins serve as cellular gatekeep-ers, regulators, and sensors. Prior studies ha...
Background: Transmembrane proteins have important roles in cells, as they are involved in energy pro...
Background A large proportion of an organism's genome encodes for membrane proteins. Membrane protei...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
For current state-of-the-art methods, the prediction of correct topology of membrane proteins has be...
Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide vari...
Abstract Background A large proportion of an organism's genome encodes for membrane proteins. Membra...
Structural information for biologically and medically interesting proteins can be difficult to obtai...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...
With the recent successes in determining membrane protein structures, we explore the tractability of...
Abstract: Transmembrane proteins allow cells to extensively communicate with the external world in a...
Background: Membrane proteins are key components in a large spectrum of diverse functions and thus a...
Membrane proteins serve as cellular gatekeepers, regulators, and sensors. Prior studies have explore...
Abstract Membrane proteins serve as cellular gatekeep-ers, regulators, and sensors. Prior studies ha...
Background: Transmembrane proteins have important roles in cells, as they are involved in energy pro...
Background A large proportion of an organism's genome encodes for membrane proteins. Membrane protei...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
For current state-of-the-art methods, the prediction of correct topology of membrane proteins has be...
Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide vari...
Abstract Background A large proportion of an organism's genome encodes for membrane proteins. Membra...
Structural information for biologically and medically interesting proteins can be difficult to obtai...
Availability of the human genome data has enabled the exploration of a huge amount of biological inf...
Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20...
Cells require membrane proteins for a wide spectrum of critical functions. Transmembrane proteins en...