Topics
embryogenesisAnatomical structure
mutantDisease
marginal zoneAnatomical structure
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B cellAnatomical structure
cell cycleTelevision show
T cellAnatomical structure
RelAgent
humoral immunitySaint
Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells. Redundancy among Rel/ NF-KB family members prompted an examination of the combined roles of c-Rel and NF-KB1 by using mice that lack both proteins. Embryonic development and the maturation of hemopoietic progenitors were unaffected in nfkb1(-/-)c-rel(-/-) mice. Peripheral T cell populations developed normally, but follicular, marginal zone, and CD5(+) peritoneal B cell populations all were reduced. In culture, a failure of mitogen-stimulated nfkb1(-/-)c-rel(-/-) B cells to proliferate was caused by a cell cycle defect in early G(1) that prevented growth. In vivo, defects in hu...
Objective: The nuclear factor-κB (NF-KB)/RelB transcription factor plays an essential role in develo...
Aging and inflammation have been shown to reduce the supply of functional B-cells; the prevailing ex...
none7siGerminal centers (GCs) are the sites where memory B cells and plasma cells producing high-aff...
Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar...
Individual Rel/NF-kappa B transcription factors, although dispensable for the development and matura...
Rel and nuclear factor (NF)-kappaB1, two members of the Rel/NF-kappaB transcription factor family, a...
AbstractRelB, a member of the NF-κB/Rel family of transcription factors, has been implicated in the ...
Targeted deletion of BAFF causes severe deficiency of splenic B cells. BAFF-R is commonly thought to...
Signaling through the canonical nuclear factor‐κB (NF‐κB) pathway is critical for the generation and...
Mice with a targeted disruption of RelB, a member of the Rel/NF-κB family of transcription factors, ...
The transcription factor family NF-kappaB/Rel is responsible for the regulation of a large number of...
M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid...
The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function ...
AbstractMultiple members of the NF-κB/Rel protein family are induced during B cell differentiation a...
The transcription factors of the Rel/NF-kappa B family function as key regulators of innate and adop...
Objective: The nuclear factor-κB (NF-KB)/RelB transcription factor plays an essential role in develo...
Aging and inflammation have been shown to reduce the supply of functional B-cells; the prevailing ex...
none7siGerminal centers (GCs) are the sites where memory B cells and plasma cells producing high-aff...
Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar...
Individual Rel/NF-kappa B transcription factors, although dispensable for the development and matura...
Rel and nuclear factor (NF)-kappaB1, two members of the Rel/NF-kappaB transcription factor family, a...
AbstractRelB, a member of the NF-κB/Rel family of transcription factors, has been implicated in the ...
Targeted deletion of BAFF causes severe deficiency of splenic B cells. BAFF-R is commonly thought to...
Signaling through the canonical nuclear factor‐κB (NF‐κB) pathway is critical for the generation and...
Mice with a targeted disruption of RelB, a member of the Rel/NF-κB family of transcription factors, ...
The transcription factor family NF-kappaB/Rel is responsible for the regulation of a large number of...
M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid...
The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function ...
AbstractMultiple members of the NF-κB/Rel protein family are induced during B cell differentiation a...
The transcription factors of the Rel/NF-kappa B family function as key regulators of innate and adop...
Objective: The nuclear factor-κB (NF-KB)/RelB transcription factor plays an essential role in develo...
Aging and inflammation have been shown to reduce the supply of functional B-cells; the prevailing ex...
none7siGerminal centers (GCs) are the sites where memory B cells and plasma cells producing high-aff...
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