Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid leukemia (AML) are limited and usually do not change the poor clinical outcome. We recently described in several chemorefractory elderly AML patients that a novel biomodulatory treatment regimen consisting of low-dose azacitidine (AZA) in combination with PPARγ agonist pioglitazone (PGZ) and all-trans retinoic acid (ATRA) induced complete remission of leukemia and also triggered myeloid differentiation with rapid increase of peripheral blood neutrophils. Herein, we further investigated our observations and comprehensively analyzed cell differentiation in primary AML blasts after treatment with ATRA, AZA, and PGZ ex vivo. The drug combination wa...
Yenny Moreno Vanegas, Talha Badar Division of Hematology-Oncology and Blood and Marrow Transplantati...
<div><p>Acute myeloid leukemia (AML) is the most common malignant myeloid disorder of progenitor cel...
Acute myeloid leukemia (AML) is a hematological malignancy with a poor prognosis attributed to eleva...
Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid le...
Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid le...
There has been an observed decrease in the global mortality from cancer, mostly atributable to impro...
DNA methylation changes are a constant feature of acute myeloid leukemia. Hypomethylating drugs such...
Introduction: Azacitidine is one of the hypomethylating agents available for the treatment of elderl...
Acute myeloid leukemia (AML) is an aggressive blood cancer with an overall survival of 30%. One form...
Introduction: Therapy for acute myeloid leukemia (AML) in elderly populations (>65\ua0years) is stil...
All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promye...
Incorporation of all-trans-retinoic acid (ATRA) into the treatment of acute promyelocytic leukemia (...
Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and m...
Leukemia is characterized by blocked hematopoietic differentiation. Blocked differentiation results ...
The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (...
Yenny Moreno Vanegas, Talha Badar Division of Hematology-Oncology and Blood and Marrow Transplantati...
<div><p>Acute myeloid leukemia (AML) is the most common malignant myeloid disorder of progenitor cel...
Acute myeloid leukemia (AML) is a hematological malignancy with a poor prognosis attributed to eleva...
Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid le...
Effective and tolerable salvage therapies for elderly patients with chemorefractory acute myeloid le...
There has been an observed decrease in the global mortality from cancer, mostly atributable to impro...
DNA methylation changes are a constant feature of acute myeloid leukemia. Hypomethylating drugs such...
Introduction: Azacitidine is one of the hypomethylating agents available for the treatment of elderl...
Acute myeloid leukemia (AML) is an aggressive blood cancer with an overall survival of 30%. One form...
Introduction: Therapy for acute myeloid leukemia (AML) in elderly populations (>65\ua0years) is stil...
All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promye...
Incorporation of all-trans-retinoic acid (ATRA) into the treatment of acute promyelocytic leukemia (...
Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and m...
Leukemia is characterized by blocked hematopoietic differentiation. Blocked differentiation results ...
The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (...
Yenny Moreno Vanegas, Talha Badar Division of Hematology-Oncology and Blood and Marrow Transplantati...
<div><p>Acute myeloid leukemia (AML) is the most common malignant myeloid disorder of progenitor cel...
Acute myeloid leukemia (AML) is a hematological malignancy with a poor prognosis attributed to eleva...